Background

CD120b is an important member of the tumor necrosis factor receptor superfamily. It is expressed on both immune cells (such as T cells, B cells, and dendritic cells) and non-immune cells (such as endothelial cells and neurons). CD120b regulates immune responses, cell proliferation, differentiation, and apoptosis by binding to its ligand TNF-α. In the immune system, activation of CD120b can promote T cell survival and function, enhancing immune responses. However, under certain pathological conditions, such as autoimmune diseases and cancer, abnormal activation of CD120b may lead to immune tolerance or suppression. Therefore, CD120b is a potential target for immune regulation and disease therapy, playing a key role in maintaining immune balance and tissue homeostasis.