Background

CD90.1 is a GPI-anchored cell surface protein and a member of the immunoglobulin superfamily. It is expressed on various cell types, including T cells, B cells, natural killer cells, dendritic cells, macrophages, and certain fibroblast subpopulations. In mice, CD90.1 is one of the two major alleles of the Thy-1 antigen, the other being CD90.2 (Thy-1.2). CD90.1 and CD90.2 are expressed in different mouse strains and are often used to distinguish cells from different sources. For example, the C57BL/6 strain primarily expresses CD90.2, while some hybrid strains may express both CD90.1 and CD90.2. CD90.1 plays important roles in immune cell recognition, adhesion, and signaling, and is also used to study cell migration, differentiation, and function. Additionally, CD90.1 has shown significant biological functions in certain disease models, such as in fibroblast subpopulations in inflammatory diseases and tumor microenvironments, where its expression is closely related to tissue fibrosis and inflammatory responses.